Ampicillin Dose

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  The ampicillin dose for an infant depends on the indication, gestational age, and weight. Here are general guidelines:

  Neonates (0–28 days)

  • Preterm (<37 weeks)

    • <7 days old: 50 mg/kg IV/IM every 12 hours
    • ≥7 days old: 50 mg/kg IV/IM every 8 hours

  • Term (≥37 weeks)

    • <7 days old: 50 mg/kg IV/IM every 8 hours
    • ≥7 days old: 50 mg/kg IV/IM every 6 hours

  Infants (>1 month)

  • Meningitis: 200–300 mg/kg/day IV divided every 6 hours
  • Serious infections (e.g., pneumonia, sepsis): 100–200 mg/kg/day IV divided every 6 hours
  • Mild to moderate infections: 50–100 mg/kg/day IV/IM divided every 6–8 hours

  Always confirm with local guidelines and adjust based on renal function, especially in preterm infants. Would you like recommendations for a specific condition?

   

  
  (Avoid ceftriaxone due to risk of bilirubin displacement leading to kernicterus)

• Acyclovir is added if herpes simplex virus (HSV) infection is suspected (e.g., maternal history of HSV, vesicular rash, seizures).

 

 

3. Hospitalization & Monitoring

• All febrile neonates are admitted for IV antibiotics and close observation until cultures return negative and the infant is clinically stable.
• Duration of treatment depends on culture results and clinical response.

4. Supportive Care

• Maintain hydration (IV fluids if necessary).
• Antipyretics (e.g., acetaminophen) are generally avoided unless fever is causing discomfort, as fever itself is not harmful but an immune response.

 

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5. Discharge Criteria

• Negative cultures after 48 hours and clinical improvement.
• If a bacterial infection is confirmed, treatment is tailored based on pathogen sensitivity.

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Newborn to 3 Months Old

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